The latest official build of aMule is 2.1.3, though you could connect to the ED2K/Kad network, you may find that the download speed is very very slow. aMule-cvs is the solution, fortunately a Chinese developer, HDFreeleader, builds the aMule-cvs snapshots weekly.

The newest build is amule-cvs-20080322. And it requires the libjpeg.62.dylib in /usr/local/lib. I recommend you to install libjpeg via MacPorts, and then create a symbolic link there.